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Angiogram with Gadofluorine P in Tumor Xenograft

Angiogram With Gadofluorine In Tumor Xenograft

In vivo angiograms of a squamous cell carcinoma xenograft derived from a contrast enhanced µCT scan (left) and a Gadofluorine P (0.05 mmol/kg = 50 µl Gadofluorine P 33.1 mg/ml vial) enhanced MRI scan at 1.5 T (right). Corresponding vessels are marked with numbers. Due to the high relaxivity of Gadofluorine P and its long blood half life vessels below 100 µm in diameter were reliably captured even when using a clinical 1.5 T MRI scanner.

Courtesy F. Kiessling, Institute of Molecular Imaging, Aachen, Germany.

Gadomer 17 shows differences in vessel maturation
in pancreatic tumor models

Vessel Maturation In Pancreatic Tumor Models

MRI images of RIP1-Tag5 wild-type (upper panel) and RIP1-Tag53 RGS knock out (lower panel) mice recorded with a 1.5 T whole-body MR scanner. RIP1-Tag5 mice develop orthotopic pancreatic tumors, which are indicated by arrows (BO, bowel; K, kidney; M, dorsal muscle; SP, spine). The left and middle images are T1w after injection of 100 mmol/kg Gadomer 17 (= 100 µl Gadomer 17 18,2 mg vial). In addition, on the images in the middle colour-coded overlays of tumor kep values (exchange rate constant) resulting from a pharmacokinetic analysis of DCE MRI data using an open two compartment model are shown.

The knock out of RGS signaling leads to an enhanced vessel maturation with decreased permeability , which is reflected by decreased kep values derived from the Gadomer enhanced DCE MRI scan.

Image taken from Hamzah et al., Nature 2008; 453:410-414

Stroke Lesions:
MR-imaging with Gadomer 17 (mice with significant extravasations)

Stroke Lesions: MR-imaging With Gadomer 17
After definition of a threshold value
a color-coded intensity picture can be obtained
(a quantification is possible).

Courtesy J. Klohs, U. Dirnagl et al. (unpublished data).

Precontrast imaging with no apparent extravasations

Stroke Imaging: Precontrast imaging with no apparent extravasations

The precontrast image (mice brain frames 9–14) shows no hints for extravasations.

Post contrast with Gadomer 17 with clearly visible extravasations

Stroke Imaging: Precontrast imaging with visible extravasations

The post contrast image shows clear areas of extravasations in the frames 10–13.
The areas are automatically coulor-coded in the difference images.
A quantitative determination of the lesioned area is possible.

Courtesy J. Klohs, U. Dirnagle, Charité, Berlin (unpublished data).